Effect of Ingestion of Trans-Fatty Acids on Lipid Metabolism in Rats

doi:10.7506/spkx1002-6630-201019080

FOOD SCIENCE ›› 2010, Vol. 31 ›› Issue (19): 363-366.doi: 10.7506/spkx1002-6630-201019080

• Nutrition & Hygiene • Previous Articles Next Articles

Effect of Ingestion of Trans-Fatty Acids on Lipid Metabolism in Rats

ZHANG Jia1，LI Jing1,*，DENG Ze-yuan1,2，CAO Jun1，LIU Rong1，FAN Ya-wei1，HU Jiang-ning1

1. State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, China；
2. Institute for Advanced Study of Nanchang University, Nanchang 330047, China

Received:2010-06-27 Online:2010-10-15 Published:2010-12-29
Contact: LI Jing E-mail:dengzy28@yahoo.com.cn

Abstract

Abstract:

Epidemiological studies have demonstrated that trans-fatty acid (TFA) intake from diet increase the risk of some chronic diseases through blood lipid metabolism and inflammation pathway. Under the condition of oil added TFA with cholesterol-free (0% cholesterol) and 33% energy supplement from fat, the effect of TFA on lipid metabolism of rats was observed during 90 d feeding. The experimental diet with TFA significantly increased TG, lowered HDL-C, LPL and HL activity, suggesting that TFA could change fatty acid profile to induce the abnormity of TG metabolism. Meanwhile, TFA significantly depressed TC and LDL-C and improved HDL-C/LDL-C ratio, but did not exhibit effect on C-reactive protein (CRP) due to having no effect on the abnormity of cholesterol metabolism.

Key words: Trans fatty acids, cholesterol metabolism, C-reactive protein, lipase

CLC Number:

TS201.2

ZHANG Jia1，LI Jing1,*，DENG Ze-yuan1,2，CAO Jun1，LIU Rong1，FAN Ya-wei1，HU Jiang-ning1. Effect of Ingestion of Trans-Fatty Acids on Lipid Metabolism in Rats[J]. FOOD SCIENCE, 2010, 31(19): 363-366.

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Effect of Ingestion of Trans-Fatty Acids on Lipid Metabolism in Rats

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