Research Process on the Effects of Food-derived Bioactive Substances on Aberrant DNA Methylation Associated with Colorectal Cancer

doi:10.7506/spkx1002-6630-201021095

FOOD SCIENCE ›› 2010, Vol. 31 ›› Issue (21): 422-426.doi: 10.7506/spkx1002-6630-201021095

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Research Process on the Effects of Food-derived Bioactive Substances on Aberrant DNA Methylation Associated with Colorectal Cancer

LIANG Yun，CHEN Qing-sen*

Tianjin Key Laboratory of Food Biotechnology, College of Biotechnology and Food Science,
Tianjin University of Commerce, Tianjin 300134, China

Received:2010-07-19 Revised:2010-10-15 Online:2010-11-15 Published:2010-12-29
Contact: CHEN Qing-sen E-mail:chqsen@tjcu.edu.cn

Abstract

Abstract:

Aberrant DNA methylation, as a vital epigenetic change, has been shown to be closely associated with the occurrence and development of colorectal cancer. This paper reviews recent progress in the mechanism of arrant DNA methylation and its importance as well as the relationship between arrant DNA methylation and colorectal cancer at home and abroad. Besides, the regulatory mechanisms of food-derived bioactive substances on DNA methylation by controlling the metabolism of methyl groups and the activity of DNA methyltransferases so as to influence the occurrence and development of colorectal cancer are herein summarized.

Key words: bioactive substances, colorectal cancer, epigenetic change, DNA methylation

CLC Number:

LIANG Yun，CHEN Qing-sen*. Research Process on the Effects of Food-derived Bioactive Substances on Aberrant DNA Methylation Associated with Colorectal Cancer[J]. FOOD SCIENCE, 2010, 31(21): 422-426.

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Research Process on the Effects of Food-derived Bioactive Substances on Aberrant DNA Methylation Associated with Colorectal Cancer

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