Abstract:

Effects of water buffaloes colostrums powder (WBCP) on serum anti-oxidative activity and organic indexes in insulindependent diabetes mellitus (IDDM) rats were studied. Insulin-dependent diabetes mellitus rats were induced by intraperitoneal injection of STZ with high-dose of 65 mg/kg bw. Rats were randomly assigned to normal group, diabetic model group, medicine group and WBCP group. With intragastric administration, sterilized water were provided to the normal and the diabetic model group, while metformin and WBCP groups were supplied for the medicine group and the WBCP group daily, respectively. Blood sugar level in fasting rats was determined regularly and blood samples were collected on day 31. Serum anti-oxidative activity was determined and internal organs were weighed and organic indexes were calculated. Compared with the diabetic model group, fasting blood sugar level drop at the beginning (P＜0.01 and P＜0.05) and serum SOD activity increased (P＜0.01), however NO concentration decreased (P＜0.05) in the WBCP group. Moreover, pancreas index and lung index decreased (P＜ 0.01 and P ＜ 0.05). In conclusion, WBCP can maintain the fasting blood sugar level at the beginning and oxidative stress is attenuated in IDDM rats with pancreases and lungs being protected.

Key words: water buffalo colostrums powder, insulin-dependent diabetes mellitus, anti-oxidation, organic index