Antioxidant Activity of Polysaccharide from Codonopsis pilosula in Aging Model Mice and Its Effect on Senescence Resistance of Fruit Flies

doi:10.7506/spkx1002-6630-201315059

FOOD SCIENCE

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Antioxidant Activity of Polysaccharide from Codonopsis pilosula in Aging Model Mice and Its Effect on Senescence Resistance of Fruit Flies

GUO Xiao-nong1，QI Huan-yang 2，WANG Bing1，DONG Jiang-ling1，JIANG Jian1，YANG Yu-jie1

1. Life Science and Engineering College, Northwest University for Nationalities, Lanzhou 730030, China；
2. Key Laboratory of Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences,
Lanzhou 730000, China

Online:2013-08-15 Published:2013-09-03
Contact: GUO Xiao-nong

Abstract

Abstract:

Objective: To explore the effect of Codonopsis pilosula polysaccharide (CPPS) on oxidation and senescence
resistance. Methods: Aging mouse models were induced by injection of D-galactose. CPPS at high, middle and low doses were
intragastrically administered to aging model mice. Malondialdehyde (MDA) content, and glutathione peroxidase (GSH-Px) and
superoxide dismutase (SOD) activities in brain and liver homogenates were measured. According to different polysaccharide
doses, the survival of fruit flies was also investigated. Results: CPPS could improve the activities of SOD and GSH-Px (P ＜ 0.05,
P ＜ 0.01) and decrease the content of MDA in brain and liver homogenates (P ＜ 0.05). The average life span and maximum
life span in the high and middle dose groups were significantly higher than those in the control group (P ＜ 0.05). Conclusion:
CPPS has obvious roles in anti-oxidation and senescence resistance.

Key words: Codonopsis pilosula polysaccharide (CPPS), anti-oxidation, senescence resistance

CLC Number:

R285.5

GUO Xiao-nong1，QI Huan-yang 2，WANG Bing1，DONG Jiang-ling1，JIANG Jian1，YANG Yu-jie1. Antioxidant Activity of Polysaccharide from Codonopsis pilosula in Aging Model Mice and Its Effect on Senescence Resistance of Fruit Flies[J]. FOOD SCIENCE, doi: 10.7506/spkx1002-6630-201315059.

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Antioxidant Activity of Polysaccharide from Codonopsis pilosula in Aging Model Mice and Its Effect on Senescence Resistance of Fruit Flies

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