Previous Articles     Next Articles

Antioxidant Activity of Polysaccharide from Codonopsis pilosula in Aging Model Mice and Its Effect on Senescence Resistance of Fruit Flies

GUO Xiao-nong1,QI Huan-yang 2,WANG Bing1,DONG Jiang-ling1,JIANG Jian1,YANG Yu-jie1   

  1. 1. Life Science and Engineering College, Northwest University for Nationalities, Lanzhou 730030, China;
    2. Key Laboratory of Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences,
    Lanzhou 730000, China
  • Online:2013-08-15 Published:2013-09-03
  • Contact: GUO Xiao-nong


Objective: To explore the effect of Codonopsis pilosula polysaccharide (CPPS) on oxidation and senescence
resistance. Methods: Aging mouse models were induced by injection of D-galactose. CPPS at high, middle and low doses were
intragastrically administered to aging model mice. Malondialdehyde (MDA) content, and glutathione peroxidase (GSH-Px) and
superoxide dismutase (SOD) activities in brain and liver homogenates were measured. According to different polysaccharide
doses, the survival of fruit flies was also investigated. Results: CPPS could improve the activities of SOD and GSH-Px (P < 0.05,
P < 0.01) and decrease the content of MDA in brain and liver homogenates (P < 0.05). The average life span and maximum
life span in the high and middle dose groups were significantly higher than those in the control group (P < 0.05). Conclusion:
CPPS has obvious roles in anti-oxidation and senescence resistance.

Key words: Codonopsis pilosula polysaccharide (CPPS), anti-oxidation, senescence resistance

CLC Number: