Determination of 11 Environmental Estrogens in Food Packaging Materials by Liquid Chromatography Coupled with Mass Spectrometry

doi:10.7506/spkx1002-6630-201308043

Abstract

Abstract: A liquid chromatography and mass spectrometry method for determination of 11 environmental estrogens in food packaging materials was developed. The samples were dissolved by dichloromethane and precipitated by methanol. The filtrates were cleaned up through C18 SPE cartridge, and then separated with liquid chromatography, detected with mass spectrometry. Average recoveries between 81.4% and 111.11% and relative standard deviations between 3.9% and 9.7% were obtained for spiked samples. The detection limits of 11 environmental estrogens were between 0.0075 mg/kg and 0.32 mg/kg.

Key words: food packaging materials, environmental estrogens, phenols, SPE, LC-MS

CLC Number:

O657.7+2

WU Zhong-ping，LU Jian*，GAO Wei，ZHANG Xiao-qiang，WANG Li. Determination of 11 Environmental Estrogens in Food Packaging Materials by Liquid Chromatography Coupled with Mass Spectrometry[J]. FOOD SCIENCE, 2013, 34(8): 204-207.

References

[1] http://www.envchem.nankai.edu.cn/script/envchem/termdetail.htm.
[2] http://baike.baidu.com/view/1865030.htm.
[3] 杜克久,徐晓白.环境雌激素研究进展[J].科学通报, 2000,45(21):2241-2251.
[4] 赵美萍,李元宗,常文保.环境雌激素的分析研究进展[J].分析化学, 2003,31(1):103-109.
[5] 邵兵,韩灏,李冬梅等.加速溶剂萃取-液相色谱-质谱/质谱法分析动物组织中的壬基酚、辛基酚和双酚A[J].色谱,2005,23(4):362-365.
[6] 王超,马强,王星等.液相色谱-串联质谱法同时测定化妆品中的16种激素[J].分析化学,2007,35(9):1257-1262.
[7] 王静,潘荷芳,文莹等.地表水中烷基酚类化合物的超高效液相色谱/串联质谱分析方法[J].中国环境监测,2008,24(5):8-11.
[8] 张奎文,叶赛,那广水.高效液相色谱-串联质谱法测定环境水体中双酚A、辛基酚、壬基酚[J].分析试验室，2008,27(8):62-66.
[9] 张朋杰,张宪臣,张静等.超高效液相色谱-串联质谱法测定食用油中的叔丁基对苯二酚 [J].食品科学,2009,30(06):143-145.
[10] 肖全伟.环境雌激素的色谱测定方法及其应用研究[D], 2006, 四川大学.
[11] 任仁,陈明,武少华,等.环境样品中烷基酚和双酚A的分析方法[J].北京工业大学学报.2004,30(3):348-353.
[12] 马强,白桦,王超等.纺织品与食品包装材料中烷基酚及双酚A迁移量的液相色谱-串联质谱分析[J].分析测试学报.科技导报,2009,28(12):1415-1418.
[13] 丁红春,李建林,徐逸云等.婴幼儿奶瓶中迁移双酚A的高效液相色谱-电喷雾串联质谱检测方法研究[J].分析化学, 2010,38(2):197-201.
[14] GB 13116-1991食品容器及包装材料用聚碳酸酯树脂卫生标准.
[15] GB 14942-1994食品容器、包装材料用聚碳酸酯成型品卫生标准.
[16] GB/T 5009.99-2003食品容器及包装材料用聚碳酸酯树脂卫生标准的分析方法.
[17] GB/T 5009.69-2008 食品罐头内壁环氧酚醛涂料卫生标准的分析方法.
[18] 黄少婵,与杭义萍.液相色谱-质谱法同时测定塑料制品中的双酚A和四溴双酚A[J].色谱,2010(9):863-866.
[19] 马强,白桦,王超等.液相色谱-串联质谱法同时测定纺织品与食品包装材料中壬基酚、辛基酚和双酚A[J].分析化学,2010,38(2):197-201.
[20] 吕刚,王利兵,刘军等.包装材料中环境雌激素的测定-固相微萃取/气相色谱质谱法[J].分析试验室,2008,27(9):73-75.
[21] GB/T 6682-2008 分析实验室用水规格和试验方法.
[22] Lagana A,Bacaloni A,De Leva I,et al.Analytical methodologies for determining the occurrence of endocrine disrupting chemicals in sewage treatment plants and natural waters[J].Anal Chim Acta,2004,501 (1):79-88.