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Chemical Composition and Antimicrobial Activity of Chimonanthus grammatus Leaves

WANG Ya1,WANG Ling-yun2,3,ZOU Zheng-rong2,ZHANG Zhi-bin2,YAN Ri-ming2,ZHU Du1,2,*   

  1. 1. Key Laboratory of Bioprocess Engineering of Jiangxi Province, College of Life Sciences, Jiangxi Science and Technology Normal
    University, Nanchang 330013, China;2. Key Laboratory of Protection and Utilization of Subtropic Plant Resources of Jiangxi
    Province, College of Life Sciences, Jiangxi Normal University, Nanchang 330022, China;3. Jiangxi Provincial Research Institute
    for Soil and Water Conservation, Nanchang 330029, China
  • Online:2013-10-15 Published:2013-09-27
  • Contact: ZHU Du

Abstract:

Objective: To study antimicrobial activity and chemical constituents in the leaves of Chimonanthus grammatus
M.C.Liu. Methods: Various chromatographic methods were adopted to isolate and purify the chemical constituents of
C. grammatus leaves and their structures were identified and elucidated according to their physicochemical properties and
spectral data. Results: Nine compounds were isolated and identified as chimonanthine (1), β-sitosterol (2), stigmasterol (3),
daucosterol (4), prenylated 4-hydroxybenzoic acid (5), (E)-4-(4,8-dimethylnona-3,7-dienyl)furan-2(5H)-one (6), diisobutyl
phthalate (7), quercetin (8) and scopoletin (9), respectively. Compounds 5, 6, 7 and 9 showed obvious antibiotic activity
against indicator microorganisms tested. Conclusion: Compounds 5, 6, 7 and 9, having good antimicrobial activity, are
isolated from plants of the genus Chimonanthus grammatus for the first time.

Key words: leaves of Chimonanthus grammatus, chemical composition, antimicrobial activity

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