Effect of Trans-fatty Acids on Fatty Acid Composition of Human Umbilical Vein Endothelial Cells

doi:10.7506/spkx1002-6630-201319056

Abstract

Abstract:

In this study, the effect of two different trans-fatty acids (TFA) on fatty acid composition of human umbilical
vein endothelial cells (HUVEC) was determined by GC. The results showed that after HUVECs were treated by elaidic
acid and linolelaidic acid, the content of trans-fatty acids rapidly increased and the content of saturated fatty acids and
polyunsaturated fatty acids exhibited a significant reduction, especially the contents of EPA, DHA and AA were obviously
affected. Both TFAs had different influences on fatty acid composition in HUVECs. Meanwhile, subjected to treatment with
linolelaidic acid, the contents of polyunsaturated fatty acids and mono-unsaturated fatty acids in HUVECs were much higher
when compared with the treatment by elaidic acids.

Key words: elaidic acid, linolelaidic acid, human umbilical vein endothelial cells, fatty acid composition

CLC Number:

R151.2

YU Hua-hong，LIANG Zhong-shuang，LI Xiang-mei，LI Jing，LIU Xiao-ru，LIU Rong，FAN Ya-wei，DENG Ze-yuan*. Effect of Trans-fatty Acids on Fatty Acid Composition of Human Umbilical Vein Endothelial Cells[J]. FOOD SCIENCE, doi: 10.7506/spkx1002-6630-201319056.

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Effect of Trans-fatty Acids on Fatty Acid Composition of Human Umbilical Vein Endothelial Cells

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