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Effect and Mechanism of Polysaccharides from Portulaca oleracea L. on STZ-Induced Diabetic Mice Fed High-Fat Diet

LIANG Yan，ZHANG Chuan-jun，LÜ Yan-rong   

  1. 1. College of Food Science and Engineering, Jilin Agricultural Science and Technology College, Jilin 132101, China;
    2. Environment Protection Agency of Fuyu, Songyuan 131200, China
  • Online:2014-02-13 Published:2014-03-17

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Abstract:

Objective: To study the anti-diabetic effect and mechanism of polysaccharides form Portulaca oleracea L.
(POPs) in STZ-induced diabetic mice fed a high-fat diet. Methods: Diabetic mice induced by streptozocin (STZ) and highfat
diet were administered with POPs and the effects of POPs on FBG, OGTT, FINS, blood lipid, SOD, CAT and MDA
were investigated. Results: POPs could improve the content of FBG and enhance FINS level. Meanwhile, POPs significantly
suppressed the increase in blood glucose after 30 min. Blood lipid of diabetic mice also decreased after POPs treatment.
Furthermore, POPs showed an obvious antioxidant effect through increasing SOD and CAT activities and decreasing MDA
content in pancreas. Conclusion: POPs have obvious anti-diabetic and anti-hyperlipidemia effects on diabetic mice and the
antioxidant effect may be a possible reason for the anti-diabetic effect.

Key words: Portulaca oleracea L., polysaccharides, diabetes mellitus, blood glucose, blood lipid, antioxidant