Abstract:

Objective: To explore the protective effect of cod skin collagen peptides with different molecular weights
on alcohol-induced gastric mucosal injury and the mechanism involved. Methods: A combination of alkali protease
and trypsin was used to hydrolyze collagen extracted from cod skin into collagen peptides different molecular weights.
The acute gastric mucosal injury model induced by high concentration of alcohol was used to examine the protective
effect of cod skin collagen peptides by determining physiological and biochemical indexes in stomach tissue and serum.
Results: Compared with the model group, collagen peptides could significantly reduce the gastric bleeding, Ca2+ content
and myeloperoxidase (MPO) activity of gastric tissue (P ＜ 0.05). In addition, medium molecular size peptides reduced the
gastric mucosal injury index to 9.21% (P ＜ 0.01) and inhibited gastric injury by 57.16%, suggesting the best protective effect.
Moreover, cod collagen peptides could increase the glycoprotein content and SOD activity of gastric tissue (P ＜ 0.05), decrease
the MDA content of gastric tissue, and increase the serum GSH level (P ＜ 0.05). Conclusion: Cod skin collagen peptides can
play a protective role on acute gastric mucosal injury in rats by enhancing the gastric mucosal barrier and antioxidant capacity.

Key words: collagen peptide, gastric mucosa, protective effect, alcohol induce, mechanism