Abstract:

Oxalate decarboxylase (Oxdc) is a homogenous polymerase with manganese ion and belongs to the Cupin
protein superfamily. In plants and microorganisms, Oxdc is one of the main enzymes which can catalyze the decomposition
of oxalate into formic acid and CO2 without cofactors. It has been applied widely in agriculture, food, industrial process,
medical, biological monitoring and other fields. In this paper, the source, structure, function and practical applications of
Oxdc are reviewed, with particular discussion on the role and advantages of Oxdc in urinary oxalate stones. This will provide
important theoretical reference for the effective prevention and treatment of urinary tract stones.

Key words: oxalic acid, oxalate decarboxylase, Cupin protein superfamily, urinary system