Abstract:

In this article, the properties of N-nitrosamines and N-nitrosoamides are introduced briefly. The hazards of
NOCs to human and animals are summarized with respect to carcinogenicity, teratogenicity and toxicity. Subsequently, the
pathways and mechanisms for the synthesis in vivo and in vitro of the N-nitroso compounds (NOCs) and the affecting factors
are discussed. Finally, the methods used to inhibit N-nitrosamines and N-nitrosoamides in vivo and in vitro by elimination
and blocking and the underlying mechanism are reviewed, aiming to provide theoretical references to fi nd other methods or
mechanisms for NOC suppression and elimination.

Key words: N-nitroso compounds, harm, synthesis, inhibition