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Progress in Research on Biofilm Formation Regulated by LuxS/AI-2 Quorum Sensing

LIU Lei1, GUI Meng2, WU Ruiyun1,3, LI Pinglan1,*   

  1. 1. Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China; 2. Beijing Fisheries Research Institute, Beijing 100068, China; 3. College of Life Sciences, Inner Mongolia University, Hohhot 010021, China
  • Online:2016-10-15 Published:2016-12-01

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Abstract:

The majority of bacteria form biofilms for growth and development and bacteria within biofilms may better adapt
to environment than their planktonic counterparts. LuxS-dependent quorum sensing is a widespread system used by bacteria
for cell-to-cell communication, which can regulate biofilm formation in a cell density-dependent manner. Autoinducer 2 (AI-2)
produced by LuxS, is a species-nonspecific signal used by both gram-negative and gram-positive bacteria for biofilm
formation. Currently, several inhibitors of LuxS/AI-2 quorum sensing have been determined to influence biofilm formation
based on their anti-AI-2 communication mechanisms. Recently, there has been a surging interest in the mechanism of biofilm
regulation by LuxS/AI-2 quorum sensing system, which is important to better understand the relationship between LuxSdependent
QS system and biofilm formation.

Key words: biofilms, LuxS/AI-2 quorum sensing, autoinducer 2, quorum sensing inhibitor, regulation mechanism

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