Abstract: Purpose: To investigate the antioxidant effect of oligopeptide extracted from Panax ginseng grown in Jilin province (GOP) on rats with D-galactose-induced oxidative damage. Methods: In total, 90 specific pathogen free (SPF) male SD rats were randomly divided into 9 groups: control group, model group, whey protein group, and six GOP groups with different doses. The rats in all groups except the control group were subjected to intraperitoneal injection of 125 mg/kg D-galactose for 6 weeks. Then, the rats in the six GOP groups were gavaged with 0.062 5, 0.125 0, 0.250 0, 0.500 0, 1.000 0 and 2.000 0 g/kg mb GOP, respectively, while those in the control and model groups were gavaged with the same volume of distilled water. The rats in the whey protein group were gavaged with 0.250 0 g/kg mb whey protein. The administration lasted for 45 days. At the same time, the rats in all groups except the control group were injected with D-galactose 125 mg/kg mb uninterruptedly. Thereafter, the oxidative stress parameters in serum and liver tissue were determined. Results: The levels of lipid peroxide and protein peroxide in the GOP groups were significantly lower than those in the model group. Meanwhile, the antioxidant enzyme activities and the antioxidant levels significantly increased compared with the model group (P < 0.05), and the antioxidant effect of GOP was better than that of whey protein. Conclusion: GOP has an antioxidant effect on rats with D-galactose-induced oxidative damage.

Key words: oligopeptide extracted from Panax ginseng grown in Jilin province (GOP), D-galactose, oxidative damage model, antioxidant