Bioactivities of Peptides Derived from Hericium erinaceus Proteins by Enzymatic Hydrolysis

doi:10.7506/spkx1002-6630-20210104-035

FOOD SCIENCE ›› 2021, Vol. 42 ›› Issue (21): 119-127.doi: 10.7506/spkx1002-6630-20210104-035

• Nutrition & Hygiene • Previous Articles Next Articles

Bioactivities of Peptides Derived from Hericium erinaceus Proteins by Enzymatic Hydrolysis

YU Yihan, DU Weining, HU Qiuhui, SU Anxiang, XU Hui, LIU Jianhui, XIE Minhao, YANG Wenjian

(1. Collaborative Innovation Center for Modern Grain Circulation and Safety, Key Laboratory of Grains and Oils Quality Control and Processing, College of Food Science and Engineering, Nanjing University of Finance and Economics, Nanjing 210023, China; 2. Nanjing Foreign Language School, Nanjing 210018, China)

Online:2021-11-15 Published:2021-11-23

Abstract

Abstract: In this study, papain, flavourzyme, alcalase and trypsin were separately used to hydrolyze Hericium erinaceus proteins, yielding peptides designated as HEPH-P, HEPH-F, HEPH-A, and HEPH-T, respectively. Their antioxidant, anti-inflammatory activity, and antitumor activities were evaluated. The results showed that HEPH-P had good 2,2-di(4-tert-octylphenyl)-1-picrylhydrazyl (DPPH) radical and hydroxyl radical-scavenging activities, with scavenging percentages of (53.01 ± 0.27)% and (55.73 ± 1.52)%, respectively. HEPH-A showed anti-inflammatory activity by effectively controlling the release of NO and interleukin (IL)-6 and promoting the secretion of IL-10 in lipopolysaccharide (LPS)-induced RAW264.7 cells. HEPH-P resulted in the rupturing of the cell membrane, triggered apoptosis and ultimately inhibited the proliferation of liver cancer cells. This study can provide a theoretical basis for the development and application of functionally active peptides from Hericium erinaceus proteins.

Key words: Hericium erinaceus; peptides; antioxidant; anti-inflammatory; antitumor

CLC Number:

TS201.2

YU Yihan, DU Weining, HU Qiuhui, SU Anxiang, XU Hui, LIU Jianhui, XIE Minhao, YANG Wenjian. Bioactivities of Peptides Derived from Hericium erinaceus Proteins by Enzymatic Hydrolysis[J]. FOOD SCIENCE, 2021, 42(21): 119-127.

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Bioactivities of Peptides Derived from Hericium erinaceus Proteins by Enzymatic Hydrolysis

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