Abstract: Dietary supplementation has increasingly become an important interventional strategy to maintain human health. With the development of high-throughput screening technology, more and more nutrients have been discovered. However, many nutrients are characterized by high lipophilicity, poor water solubility, poor stability and low bioavailability. Hence, the design and development of delivery systems for lipophilic nutrients have received extensive attention. Emulsion-based delivery systems have been reported to effectively improve bioavailability of lipophilic nutrients. According to the characteristics of the two-phase interface in emulsions, this paper aims to review the regulation of the interface design of lipid-based emulsions (including simple and complex interfaces) on the bioavailability of lipophilic nutrients for the purpose of providing a reference for improving the bioavailability of lipophilic nutrients.

Key words: emulsions; interface; nutrients; digestion; bioavailability