Abstract: Sucrose possessed eight hydroxyl positions suitable for derivation of three primary and five secondary hydroxylgroups. These eight hydroxyl groups were responsible for the sweetness of sucrose. Strong enhancement of sweetness ofsucrose has been achieved by replacing specific hydroxyl groups, namely those at C-4, C-1’, C-4’ and C-6’, in the glucosyl andthe fructoside units of sucrose, but not at the 6-OH group, with highly lipophilic chlorine atoms. The high sweetness intensityof sucrose derivatives was very stereospecific. Thus it was important to research on the relationship between structure andsweetness of sucrose derivatives. Today, the sweetness mechanism of sucrose derivatives was essentially explained by the AH-B-γtheory and the multipoint attachment theory.

Key words: sucrose derivatives, structure, sweetness, halogens, substituent, AH-B-γtheory, the multipoint attachment theory中图分类号:O629.11 文献标识码:A 文章编号-6630(2003)05-0029-05