Abstract: Ah igh-performancel iquidc hromatographym ethodf or them ulti-residuess imultaneous determinationo fs ulfadiazine, sulfamethazine, sulfamethoxypyridazine, sulfamonomethoxine, sulfamethoxazole, sulfadimethoxine and sulfaquinoxaline in eggs was described in this paper. The egg samples were extracted with dichloromethane, and cleaned upon by a C18 column solid- phase extraction (SPE). The calibration curves for seven sulfonamides were linear in a concentration range of 0.02～1.0μg/ml (R2=0.9995～0.9999).The recoveries at levels of 0.05,0.1,0.2mg/kg fortified samples ranged from 73.2%～102.6%, with coefficient of variation of 1.8%～8.7%. The limits of detection were 0.02mg/kg and the limits of quantification less than 0.05mg/kg.

Key words: sulfonamides, egg, muti-residues, SPE, HPLC-DAD