Abstract: This paper studyed the efficacy of water extracts of Discolored Cinquefoil Herb on boosting metabolism of glucose of mice liver cell inv itro. The results showed that water extracts of Discolored Cinquefoil Herb could increase the ability of glucose intakea ndm etabolismo f thei nsulin-resistantm icel iver cellsi n vitro( p<0.05).F urthermore,t he watere xtractsc ouldh elpn ormal micel iverc ells in vitro make better use of glucose (p<0.01).T he resultsi ndicatedt hatl iver cellse xposed to5 ×10 -7 mol/L insulin for 16h were able to induce a state of insulin-resistance. And the concentration of 0.9mg/ml water extracts of Discolor Cinquefoil Herb had the strongest capability of increasing metabolism of glucose.

Key words: Discolor cinquefoil herb, cell culture, insulin-resistant, metabolism of glucose