FOOD SCIENCE ›› 2005, Vol. 26 ›› Issue (8): 392-394.

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Effect of Anti-cerebral Ischemia of Gross Saponin of Chicory

LI  Jing, CHANG  You-Quan, QU  Hong-Guang, YIN  Er-Li, CHANG  Xi-Tao   

  1. 1.Jilin Normal Institute of Engineering and Techology;2.Key Laboratory for Molecular Enzymology and Engineering of Ministry of Educational Jilin University;3.Baichang Central Hospital of Jilin Province
  • Online:2005-08-15 Published:2011-09-19

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Abstract: Objective: To study the effect of anti-cerebral ischemia of GSC. Methods: A focal cerebral ischemia model was set up through blocking one-side medium cerebral artery, the effects on infarction area and behavior scoring(neuological deficits) of GSC were observed; blood stasis model was built in rats , the effects on platelet aggregation rate and clotting time of GSC were observed. Results: GSC with dose of 10.4, 20.8 and 31.2mg/kg could significantly decrase the infarction area and improve behavior score(p<0.05, p<0.01); GSC with dose of 10.4, 20.8 and 31.2mg/kg could remarkably decrase the platelets aggregation rate(p<0.05) , and markedly prolong the clotting time in blood stasis rats. Conclusion: GSC have the effect of anti- cerebral ischemia and its mechanism may be related to lowering platelets aggregation rate and prolonging clotting time.

Key words: GSC, cerebral ischemia, infarction area, behavior score, platelets aggregation rate clotting time