FOOD SCIENCE ›› 2005, Vol. 26 ›› Issue (9): 484-486.

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Study on Antithrombosis of Gross Saponin of Tribulus Terrestris Injection

 ZHENG  Hong-Yan, CHANG  You-Quan, QU  Hong-Guang, MA  Jin-Rong, MA  Yan, XI  Xiao-Wei   

  1. 1.Jilin Agricultural University;2.The Pharmacology of Basic Medical School of Jilin University; 3.Jilin Normal Institute of Engineering and Technology; 4.Baicheng Central Hospital of Jilin Province
  • Online:2005-09-15 Published:2011-09-20

Abstract: Objective: To study the effect on thrombosis in vivo and in vitro of SC. Method (1) To observe the effect of SC on thrombus wet weight and thrombosis time of rats in vivo, through Methods of Neck Artery-Vein Side-way Thrombosis and Artery Trombosis induced by electricity stimulation, and to observe the effect of SC on the thrombus lenghth, and thrombus wet and dry weight in rats in vitro.(2) To observe the effect of SC on the blood viscosity in blood stasis rats.Result (1) SC with dose of 20.8, 31.2mg/kg can significantly decrease thrombus wet weight(p<0.05,p<0.01), and prolong thrombosis time(p< 0.01), and shorten the thrombus lenghth(p<0.05), and decrease thrombus wet and dry weight(p<0.01,p<0.05). (2) SC with dose of 20.8,31.2mg/kg can significantly decrease blood viscosity(p<0.01). Conclusion: SC have the effect of antithrombosis, and its mechanism involves viscosity, hemorheology.

Key words: SC thrombosis, thrombus wet weight, thrombus dry weight, thrombus lenghth blood viscosity