Abstract: The Comus officinalis is rich in total saponins, dogwood tanning substance, phenol class, ursolic acid, gallic acid and so on. This article takes the Comus officinalis as a raw material, crries on the total soap saponins of Comus officinalis cated to several kinds of common food putrefactive bacterias and pathogenic bacteria’s antimicrobial effect to conduct the research. The test result indicated: the total soap saponins of Comus officinalis is in particular obvious to the Staphylococcus aureus suppression effect, is bad to the Saccharomycetes and mold’s suppression effect; This material to the Staphylococcus aureus lowest bacteriostasis density is 24.82mg/ml; The total soap saponins of Comus officinalis best bacteriostasis pH is 3 also the soap saponins glucoside thermostability is good; at 121℃, for 25min processing still maintained the good antimicrobial effect.

Key words: Comus officinalis, total saponins, antibacterial action