Abstract: Objective: To study the influence of soy isoflavones on serum lipid level in Hyperlipidemia rats. Methods: 50 SD female rats were randomly divided in 4 groups: normal diet control, high fat diet, low dose SI (300mg/kg bw)+high fat diet, and high dose SI (600mg/kg bw) + high fat diet; rats of normal diet control were fed with normal diet, and rats of the remainder groups were fed with high fat diet. After 6 weeks, rats were killed and have detected serum lipid level and activity of LPL and HL in blood. Results: Compared with the group of SI diet, the TC, TG, LDL-C levels of the group of high fat diet were significantly higher, the HDL-C level were significantly lower, the activity of LPL in serum increased obviously. Conclusion: These results suggested that soy Isoflavones can decrease the serum lipid level obviously.

Key words:  , soy isoflavones； serum lipid； LPL； HL；