Abstract: Molecular mechanics and quantumchemistry methods was used to study the effect quarititative structure-activity relationship (QSAR) on the antioxidative activities of yakuchinone A and curcumin. The energy and electronic structures of the curcumin compounds including yakuchinone A and curcumin were calculated. The change of enery and electronic structure from free radicals were acounted and like curcumin compounds there the active process of the curcumin compounds dehydrogenation oxidation was take place. Results showed that the structure stabilities of curcumin and yakuchinone A are reactive to their moleculars tructure.

Key words: Alpinia oxyphylla, antioxidant, QSAR(quantitative structure activity relationship)