Abstract: The aims of this paper are to provide a selective review of the interactions between food and gastrointestinal mucosa, TLRs, cytokine system, and immunosystem. More and more research data showed that a few food proteins, peptides, fats, oligosaccharides and other biochemicals can induce or suppress one kind of both pro- and anti-inflammatory cytokines, which are in turn to control innate, adaptive immnnosystems, neurophysiology and metabolic networks. More and more strong evidence showed that the relationship and balance between pro- and anti-inflammatory cytokines are seem to be very similar to those of the Chinese“ Yin”“-negative, or-” and“ Yang”-“ positive, or +”. Chinese people have classified food and herb medicines according to their experience of their positive or negative roles, and also believed that one can modulate his health by controlling the balance of Yin (-) and Yang (+) of food and herb medicine’s intake. So a theoretical model is induced in this paper to explicate the interactions of food and cytokine system and in turn the immunosystem and then the body health.

Key words:  , cytokine system； immunology； food science； pro-inflammatory cytokine； anti-inflammatory cytokine； theoreticalm odel；