Study on Antitumor Inhibition of Soyasaponins on Hepatocarcinoma H22 Mice

Abstract

Abstract: Using hepatocarcinoma H22 tumor-bearing mice as model, the inhihifion effect of soyasaponin fraction (SSⅡ) on hepatocarcinoma H22 mice was observed at dosages of 10, 20 and 30mg/kg/day by systematically studying the H22 tumor inhibition rate, cellular immunity and antioxidant level. In this study, SSⅡinhibited the growth of transplanted hepatocarcinoma H22, increased the DTH response, promoted the proliferation of T lymphocyte and NK cell activity significantly, improved the superoxide dismutase (SOD) activity and decreased the malondialdehyde (MDA) content significantly. The mechanism of SSⅡ about antitumor inhibition might be the enhancing of the cellular immune function and the improving of the antioxidant capability in H22 tumor-bearing mice.

Key words: , soyasaponins SSⅡ； hepatocarcinoma H2； 2cellular immunity； antioxidant；

XIAO Jun-Xia, ZHU Cai-Ping, REN Dan-Dan, HUANG Hong-Xia, ZHANG Sheng-Hua. Study on Antitumor Inhibition of Soyasaponins on Hepatocarcinoma H22 Mice[J]. FOOD SCIENCE, 2006, 27(6): 203-206.

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Study on Antitumor Inhibition of Soyasaponins on Hepatocarcinoma H22 Mice

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