Abstract: Effects on learning and memorizing abilities of varied model mice fed with transgenic metallothinoein(MT)mushroom were studied in this paper.The results showed that the dried transgenic MT mushroom could significantly improve learning ability of early adulthood mice and lead poisoning mice when there was 1% MT mushroom in mixed feed(corresponding to doses of 1kg/d to human whose body weight is 50～60kg).No further improvement was found when MT mushroom dosage increased.The dosage of 3.16% MT mushroom could significantly improve the memorizing ability of early adulthood mice,but there was no effect on improvement of learning and memorizing ability to senile mice caused by injecting D-galactose under skin with both dosage of 1% and 3.16% MT mushroom.

Key words:  , metallothionein； transgenic； mushroom； mice； learning and memorizing ability；