Lyophiled Royal Jelly In vitro and In vivo Hypoglycemic Studies on Effects of Glucose Consumption in Cultured HepG2 Cells and Blood Sugar in Alloxan-induced Diabetic Mice

FOOD SCIENCE ›› 2006, Vol. 27 ›› Issue (9): 233-235.

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Lyophiled Royal Jelly In vitro and In vivo Hypoglycemic Studies on Effects of Glucose Consumption in Cultured HepG2 Cells and Blood Sugar in Alloxan-induced Diabetic Mice

WANG Ning, Zhu-Quan, Zhou-Yi-Wei, Tong-Huang-Jin

1.Department of Pharmacy, Anhui College of TCM, Hefei 230031, China;2.National Standard Laboratory of Pharmacology for Chinese Materia Medicine at Nanjing University of TCM, Nanjing 210029, China

Online:2006-09-15 Published:2011-10-20

Abstract

Abstract: Objective: To observe the hypoglycemic effects of royal jelly in vitro and in vivo. Methods: HepG2 cells, the phenotype of which is similar to that of the human hepatocytes, were used to assay the 24h, consumption of glucose in cultured fluid. MTT assay was used to monitor the proliferation of the HepG2 cells. The experimental diabetic mice induced by alloxan well established and determined with the changes of blood sugar in diabetic mice. Conclusions: Royal jelly could increase the glucose consumption of HepG2 cells and enhance the glucose consumption in synergism with insulin. Lyophiled royal jelly could also decrease significantly the blood sugar in alloxan-induced diabetic mice.

Key words: , royal jelly； HepG2 cell； diabetes； alloxan； glucose consumption； blood sugar；

WANG Ning, Zhu-Quan, Zhou-Yi-Wei, Tong-Huang-Jin. Lyophiled Royal Jelly In vitro and In vivo Hypoglycemic Studies on Effects of Glucose Consumption in Cultured HepG2 Cells and Blood Sugar in Alloxan-induced Diabetic Mice[J]. FOOD SCIENCE, 2006, 27(9): 233-235.

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Lyophiled Royal Jelly In vitro and In vivo Hypoglycemic Studies on Effects of Glucose Consumption in Cultured HepG2 Cells and Blood Sugar in Alloxan-induced Diabetic Mice

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