Anti-inflammation and Analgesic Experimental Study on Citrus Frutis Limonoids

Abstract

Abstract: Objective: To study the anti- inflammation and analgesic effects of citrus frutis limonoids. Methods: The analgesic effects of limonoids were assayed by formaldehyde test and writhing test in mice. The anti-inflammation effects of limonoids were tested by both mouse’s ears edemata caused by dimethylbenzene and rat’s meta tarsus edemata caused by para-carrageenan. Result: Limonoids from citrus frutis can inhibit the nociceptive response by formaldehyde, reduce the writhing number, and obviously inhibit edemata of the mouse’s ears by dimethyienzene and of the rat’s tarsus caused by para-carrageenin. Conclusions: Limonoids from citrus frutis have potent anti-inflamation and analgesic effect.

Key words: limonin, anti-inflamation, analgesic

WEN Jing, SHI Ying, XU Yu-Juan, XIAO Geng-Sheng, ZHANG You-Sheng. Anti-inflammation and Analgesic Experimental Study on Citrus Frutis Limonoids[J]. FOOD SCIENCE, 2007, 28(11): 515-518.

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Anti-inflammation and Analgesic Experimental Study on Citrus Frutis Limonoids

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