Abstract: Objective: To investigate the effect of CGMP with different doses on intestinal flora in mice. Methods: 60 BALB/ c mices were divided into ten groups(controls and 4～10 groups).The control 1group was administered only normal fodder. The control 2 group was administered sweet whey at dose of 0.2 ml/d. The control 3 group was received the equal volume of normal saline, and the 4～10 groups were administered the equal volume of CGMP which were of different consistencies for 15d. We analyzed the intestinal flora at 0(before terminating), 3, 5, 7, 10, 15d and 22d (after terminating CGMP for 1 week) and observed the vary regular of the intestinal flora in each group. Results: The number of Bifidobacterium and Lactobacillus increased (p< 0.01), pathogenesis decreased(p<0.05), Enterobacter, Enterococcus had no obvious change on the whole in experimental groups compared with the controls in the intestine and faeces. There is a best dose(100μg/d) in the experiment, and the number of pathogenesis, Enterobacter, Enterococcus decreased obviously in the group 8(100μg/d). This experiment demonstrated that CGMP have had the function of regulating the intestinal flora.

Key words: CGMP, intestinal flora, faeces