Abstract: The effects of GPS on the phagocytosis capability, energy metabolism level, IL-1、 IL-6 and IL-12 activity were assayed by adding different concentration of GPS into cultured mouse peritoncal macrophages in vitro. The results showed that the effects of GPS on the phagocytosis capability, energy metabolism level, IL-1, IL-6 and IL-12 activity are significantly higher than those in the control group (p<0.01). Concentration of GPS is 600μg/ml, mensurations of the GPS groups index basically were higher than the masculine control groups except of IL-12. It indicated that GPS can activate macrophages to secrete many kinds of active factors with tumoricidal activiy, and enhance its phagocytosis capability and energy metabolism level. It can conclude that the opitimum adding concentration of GPS is 600μg/ml.

Key words: glycyrrhiza polysaccharid, acrophage, cytokine