FOOD SCIENCE ›› 2019, Vol. 40 ›› Issue (11): 175-181.doi: 10.7506/spkx1002-6630-20180305-051

• Nutrition & Hygiene • Previous Articles     Next Articles

Pu-erh Tea Inhibits Body Mass Gain and Modulates Cytokine Profiles of Nutritionally Obese Sprague-Dawley Rats

FENG Wei1, WANG Xueqing1,*, CHEN Pei1, AN Wenwen1, ZHANG Chaoying1, LI Shengying1, YAN Qiang1, WANG Pengji1, BAI Xiaoli2, LI Changwen2   

  1. 1. Tianjin Key Laboratory of Food Biotechnology, College of Biotechnology and Food Science, Tianjin University of Commerce, Tianjin 300134, China; 2. Yunnan Tasly Deepure Biological Tea Group Company Limited, Puer 665100, China
  • Online:2019-06-15 Published:2019-06-28

Abstract: In order to explore the antiobesity mechanism and health benefits of Pu-erh tea, SD rats with normal body mass were used as the normal control group, and nutritionally induced obese SD rats were randomly divided into five groups of 8 rats each: obese model group, sibutramine positive control group, and low-, middle-, and high-dose Pu-erh tea groups. The rats were administered with Pu-erh tea by gavage for 42 successive days, and their body masses were measured once a week. Glucose (Glu), insulin, leptin, adiponectin, tumor necrosis factor-alpha (TNF-α), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), interleukin-1 alpha/beta (IL-1α/β) and vascular endothelial growth factor (VEGF) levels were determined in the serum of rats in each group after 24 h fasting. Compared with the obese control, the body mass in the low-, middle-, and high-dose Pu-erh tea groups decreased by 24.8%, 26.59% and 27.62% (P < 0.05), respectively, serum Glu by 57.3%, 67.1% and 72.7% (P < 0.01), LDL-C by 7.11%, 9.11% and 25.74% (P < 0.05), insulin by 8.6%, 17.2% and 41.7%, leptin by 68.6%, 66.8%, 64.6% (P < 0.01), VEGF by 45.3%, 44.6%, 40.5% (P < 0.01), and TNF-α by 25.0%, 27.8%, 33.3% (P < 0.01); whereas HDL-C significantly increased by 20.4%, 22.2% and 25.0% (P < 0.05), and adiponectin by 5.9%, 7.6% and 9.7% (P < 0.05), respectively. Moreover, Pu-erh tea increased IL-1α and reduced IL-1β, thereby modulating the ratio of IL-1α to IL-1β. Therefore, Pu-erh tea obviously reduces body mass gain and modulates cytokine profiles in high-fat diet-induced obese rats.

Key words: Pu-erh tea, nutritional adiposity, cytokines, body mass

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