FOOD SCIENCE ›› 2007, Vol. 28 ›› Issue (2): 305-308.

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Study on Radioprotection Effects of Angelica sinensis Polysaccharides on Sub-acute Radiation-injured Mouse

 SUN  Yuan-Lin, GU  Xiao-Hong, LI  De-Yuan, TANG  Jian   

  1. 1. Department of Life Sciences, Yuncheng University, Yuncheng 044000, China;2. Key Laboratory of Food Science and Safety, Ministry of Education, Southern Yangtze University, Wuxi 214036, China;3. Testing and Analysis Center, Southern Yangtze University , Wuxi 214036, China;4. Nutrition and Food Research Institute, Wuhan Economic College, Wuhan 430035, China
  • Online:2007-02-15 Published:2011-12-31

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Abstract: Objective: To investigate the radioprotective effect of Angelica sinensis polysaccharide ASP3 on sub-acute radiation- injured mice. Methods: Polysaccharide ASP3, prepared from Angelica sinensis, was orally administered to groups of mice. After being exposed wholely to 60Coγ-rays once, peripheral leucocyte and lymphocyte counts, micronuclei frequency of PCE in bone marrow, transformation rates of peripheral lymphocyte, SOD and MDA of liver cells were examined. Results: ASP3 could protect leucocytes and lymphocytes, prohibit formation of micronucleus of polychromatic erythrocytes in bone-marrow, speed trans- formation rate of peripheral lymphocytes, content of SOD of liver cells and enhance the radiation endurance of the body. Conclusion: ASP3 has radioprotective effects on sub-acute radiation-injured mice.

Key words: Angelica sinensis, sub-acute radiation, radioprotection