Abstract: Objective: Study on the effects of Paederia scandens extracts (PSE) on blood glucose, blood lipid in ICR diabetic mice. Methods: Diabetic models were induced by giving hyperglucose, hyperlipid and the i.v. injection of strepotozotocin (STZ) in ICR mice, and were divided into different groups which were given 2.6, 1.3 g/kg PSE, metformin or normal water respectively. Blood glucose, TG, CHO, HDL-C, LDL-C and food, water intake and body weight were respectively tested. Results: After 30d drug administration, symptoms of diabetic mice fed PSE were alleviated obviously. PSE can decrease food intake of diabetic mice, and increase their body weight. High dose of PSE lowered the level of blood glucose by 7.6% and two doses of PSE lowered the levels of TG, and increase the level of HDL-C, especially the high dose PSE lowered the TG by 24.67%. Conclusion: PSE can have the hypoglycemic effect to some extent and alleviate the diabetic symptoms on diabetic mice.

Key words: Paederia scandens, diabetes mellitus, ICR mice, blood glucose, blood lipid