Study on Biological Functions of Spirulina platensis Phycocyanin and Its Hydrolysates by Trypsinase

Abstract

Abstract: The separation and extraction of phycocyanin from S. platensis were studied. MTT and ELISA assays were employed to evaluate the effects of S.platensis phycocyanin and its hydrolysates by trypsinase on the cell growth and on the Caspase-3 activity of HeLa cells. The results indicated that the purified phycocyanin and its hydralysates have obvious inhibition effects on the proliferation of HeLa cells in vitro. The inhibition rates on HeLa cells of 100 mg/L the phycocyanin and its hydralysates are 29.2% and 56.5%,respectively. It was also found that the Caspase-3 activity of HeLa cells treated with phycocyanin (100 mg/L) after12 h rises obviously.

Key words: phycocyanin, hydrolysates, biological functions, Caspase-3

WANG Xue-Qing, FAN Min, YANG Chun-Yan, XIA Chao-Gang, ZHANG Zhong-Ying. Study on Biological Functions of Spirulina platensis Phycocyanin and Its Hydrolysates by Trypsinase[J]. FOOD SCIENCE, 2008, 29(10): 433-435.

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Study on Biological Functions of Spirulina platensis Phycocyanin and Its Hydrolysates by Trypsinase

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