Anti-tumor Effects of Silkworm Pupa Protein Polypeptides in vitro and in vivo

Abstract

Abstract: According to the results of this study,the inhibition effects of silkworm pupa protein polypetides to on A549 and Ketr-3 cells proliferation are directly proportional to the polypeptides concentration in the range of 0.5 to 1.5 g/L.The polypetides cause a significant G2～M,G0～G1 phase arrest in A549 and Ketr-3 cells respectively.With the dosage of 150 to 600 mg/kg,the polypeptides inhibit sarcinoma 180 by 28.72% to 58.18% and hepatocarcinoma 22 by 27.64% to 63.88%,and significantly prolong the life span of the EAC-bearing mice.As a conclusion,the silkworm supa protein polypeptides has significant anti-tumor effects.

Key words: silkworm pupa protein, polypeptides, anti-tumor

YAN Qi-Tao, CAO Bai-Ying, CHANG You-Quan. Anti-tumor Effects of Silkworm Pupa Protein Polypeptides in vitro and in vivo[J]. FOOD SCIENCE, 2008, 29(11): 588-590.

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Anti-tumor Effects of Silkworm Pupa Protein Polypeptides in vitro and in vivo

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