Abstract: Seven types of macroporous resin were compared on their adsorption and desorption performances to α-glucosidase inhibitor from fermentation broth of Streptomyces sp. DO406. The optimal resin was selected and its dynamic adsorption characterisyics and desorption conditions were studied. Results showed that SZ4 resin presents the highest adsorption and desorption capacities to theα-glucosidase inhibitor,and its optimal adsorption conditions are:pH 6.0 and flow rate 4.5 BV/h. The maximum adsorption is 6.3×103 U/g resin. When 30% ethnal is used as eluant,the desorption rate is 88%. SZ4 shows better adsorption and desorption capacity to α-glucosidase inhibitor,so it is appropriate to separate α-glucosidase inhibitor from fermentation broth.

Key words: fermentation broth； &alpha, -glucosidase inhibitor； macroporous resin； adsorption； seperation；