In vitro Inhibition of Quercetin-polyethylene Glycol Solid Dispersions against Nitroso Reaction

Abstract

Abstract: The quercetin was prepared from Flos Sophorae Immaturus. To improve the solubility of quercetin in aqueous solution, the solid dispersions of quercetin-polyethyleneglycol were prepared by fusion method so as to increase quercetin as solid dispersion in water from 11.8μg/ml to 80.2μg/ml. Under the simulated gastric solution, the nitrosation inhibition was studied. The results showed that the solid dispersions of quercetin-polyethylene glycol have strong effects on disconnecting NDMA and scavenging sodium nitrite. The maximum disconnecting rate of NDMA is 91.3%, and the maximum scavenging rate of sodium nitrite is 86.1%.

Key words: quercetin, polyethyleneglycol, solid dispersions, nitrosamine

WU Chun, CHE Chun-Bo, LI Jun-Sheng, DAI Li-Jun. In vitro Inhibition of Quercetin-polyethylene Glycol Solid Dispersions against Nitroso Reaction[J]. FOOD SCIENCE, 2008, 29(3): 53-55.

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In vitro Inhibition of Quercetin-polyethylene Glycol Solid Dispersions against Nitroso Reaction

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