Abstract: Objective: To investigate the subacute toxicity of riceflower -perfume energy liquor (RPES) to rat. Methods: Sixty wister rats were randomly divided into three experiment groups and one control group (8 females and 7 males in each group). The rats from experiment groups were orally administrated with RPEL at 9:00 AM every morning for 45 days, with a high dosage (3. 44 ml/kg), medium dosage (1.72ml/kg), low dosage (0.86 ml/kg) respectively; and those from the control group were orally administrated with distilled water(1.72ml/kg). Meanwhile, the changes of body weight were measured every week. Experiments for blood routine, liver function, liver organ index and pathological examinations of heart, lung, speen, kidney were carried out after the last use of the liquor. Results: Indexes of blood routine, liver function in the three experiment groups have no statistical difference compared with that of the control group.The changes of body weight show significant difference between the male rats and the female rats. No abnormal changes are found in pathological examinations of heart, lung, spleen, kidney, but the RPEL can induce liver damage. The severity of liver damage is dose-dependent. Conclusion: The RPEL has liver toxic effects on the rats.

Key words: riceflower-perfume energy liquor (RPEL), rat, subacute toxicity