Abstract: Objective: To study the immunemodulatory effect of Indian ginseng root extract (IGRE) growing in Chongqing. Methods: Mice were fed with IGRE at dose of 5, 2.5, 0.85 g/kg bw for 30 days, then their immune function were studied. Results: IRRE could stimulate response of delayed hypersensitivity. The proliferation of ConA-induced mitogenic reponse for spleen lymphocyte are also increased. Only in the high dose group and medium dose group the amount of hemolytic antibody in mice serum increases and the percentage as well as index of phagocytosis of celiac macrophage enhances compared with those of the control group mice. Further, marrow DNA content and serum NO content in all dose groups are higher than those of mice in the control group, while the activities of acid phosphatase and alkalinity phosphatase of mice serum only in the high dose group are higher than those of mice serum in the control group. Conclusion: Indian ginseng root extract can enhance immunce function of mice.

Key words: Indian ginseng, immune effect, DNA content, NO content, activity of phosphatase