Liposomal Propolis Flavone Extract:Preparation and in vitro Controlled Release Characteristics

Abstract

Abstract: The process parameters for preparing liposomal propolis flavone extract were preliminarily optimized using uniform design with mean diameter of liposome,encapsulation efficiency,and storage stability of liposome as major indexes. Based on in vitro controlled release characteristics of liposomal propolis flavone extract,its optimum preparation conditions are determined as follows:egg lecithin 500 mg,cholesterol 80 mg,propolis 100 mg,rotary evaporating temperature 45 ℃,phosphate buffer solution(pH 7.4) 25 ml and ultrasonic treatment time 25 min. The resultant liposomal propolis flavone extract shows an encapsulation efficiency of 86.6% with a mean diameter of 104.78 nm and a percentage encapsulation efficiency retention rate of 77.0%.

Key words: propolis flavone extract, liposome, uniform design, in vitro release characteristics

DAN Liang, TANG Zhi-Yong, LIU Yuan-Fa, JIN Qing-Zhe, WANG Xing-Guo. Liposomal Propolis Flavone Extract:Preparation and in vitro Controlled Release Characteristics[J]. FOOD SCIENCE, 2008, 29(8): 232-237 https://doi.org/

[1]	YU Haiqi, YAO Bingxu, WANG Xinlu, WANG Yudan, WANG Meng. Puerarin-Loaded Liposomes Alleviate Deoxynivalenol-Induced Ferroptosis in Neuronal Cells [J]. FOOD SCIENCE, 2026, 47(9): 8-17.
[2]	XIANG Huan, ZHAO Juanjuan, HUANG Hui, CHEN Shengjun, ZHAO Yongqiang, LIU Yuhang, HAO Zhiqiang, HAO Shuxian. Effects of Different Carriers on the Digestion and Absorption of Astaxanthin from Litopenaeus vannamei [J]. FOOD SCIENCE, 2025, 46(9): 80-90.
[3]	YU Shaoxuan, PANG Geyu, ZHANG Zihao, LI Shiyang, XU Shuo, XIAO Haifang, ZHU Lanlan, SONG Yuanda. Preparation, Modification and Characterization of Nanoliposomes Loaded with Curcumin and Reduced Glutathione [J]. FOOD SCIENCE, 2024, 45(6): 32-40.
[4]	LI Qiaoling, LI Henian, GUO Jingke, ZHU Zeliang, TENG Wei, HU Yujia, LUO Yuanyuan, WANG Mengtian, LIU Shutao. Ameliorative Effect of Orally Administered Nano-Superoxide Dismutase Liposomes on Ulcerative Colitis in Mice [J]. FOOD SCIENCE, 2023, 44(1): 166-174.
[5]	LI Chang, XUE Lu, LU Jing, PANG Xiaoyang, ZHANG Shuwen, LÜ Jiaping. Preparation and Characterization of Docosahexaenoic Acid Algae-Rich Oil Liposomes by High-Pressure Microfluidizer Homogenization [J]. FOOD SCIENCE, 2022, 43(19): 110-117.
[6]	ZHANG Ting, WEN Hedi, SONG Jingyi, GE Huifang, WANG Minghua, CHEN Yan, LIU Boqun, LIU Jingbo. Preparation and in Vivo and in Vitro Sustained-Release Characteristics of Egg White Peptide Liposomes by Ethanol Injection Combined with High-Pressure Homogenization [J]. FOOD SCIENCE, 2021, 42(13): 79-86.
[7]	CHEN Chong, ZHAO Mouming, SUN Weizheng. Antioxidant Activity and Electron-Donating Capacity of Tyr-Containing Dipeptides in Liposomal Systems [J]. FOOD SCIENCE, 2021, 42(11): 1-7.
[8]	LI Yuhao, LI Zhaoying, ZHOU Wei, FU Tiaokun, ZOU Liqiang, PENG Shengfeng, CHENG Ce, LIU Wei. Effects of Pitaya Stem Phytosterol on Stability and Release Properties of Curcumin Nanoliposomes [J]. FOOD SCIENCE, 2020, 41(16): 68-76.
[9]	GUAN Huanan, HAN Bolin, GONG Dezhuang, YAN Xiufeng. Fabrication of Enzyme Nano-Biosensor Based on Liposome Bioreactor for Rapid Detection of Dichlorvos [J]. FOOD SCIENCE, 2019, 40(8): 280-286.
[10]	FU Mi, YU Jiali, GUO Liang, LI Yanhua, CHEN Jie, MENG Yuecheng. Stability and Antibacterial Activity of Nisin-Loaded Liposomes under Different pH Conditions [J]. FOOD SCIENCE, 2019, 40(21): 7-13.
[11]	LIU Weilin, KONG Youyu, XU Xiankang, ZHENG Lingyi, LIU Yefei, HAN Jianzhong. LIU Weilin, KONG Youyu, XU Xiankang, ZHENG Lingyi, LIU Yefei, HAN Jianzhong [J]. FOOD SCIENCE, 2019, 40(20): 81-86.
[12]	TAI Kedong, ZHAO Sumao, YANG Ziheng, MAO Like, GAO Yanxiang, YUAN Fang. Effect of High-Pressure Homogenization on Vesicle Characteristics and Stability of Liposomes [J]. FOOD SCIENCE, 2019, 40(17): 169-177.
[13]	ZHU Yuqing, LIU Wei, CHEN Xing, CHENG Ce, ZOU Liqiang. Preparation and Properties of Curcumin Nanoliposomes Modified by Folic Acid-Chitosan Complex [J]. FOOD SCIENCE, 2018, 39(24): 7-13.
[14]	WANG Zhe, GUAN Rongfa, LIU Zhenfeng, WANG Wei, XIAO Chaogeng, ZHANG Xiaojun, Lü Fei. Effect of Lysozyme Liposomes on Trachinotus ovatus Preservation [J]. FOOD SCIENCE, 2018, 39(11): 227-232.
[15]	YIN Hao, CHEN Ya, TAO Tao, XIE Bijun, SUN Zhida. Preparation, Stability and Antioxidant Activity of Lotus Seedpod Oligomeric Procyanidin Nanoliposome [J]. FOOD SCIENCE, 2018, 39(10): 97-105.

Liposomal Propolis Flavone Extract:Preparation and in vitro Controlled Release Characteristics

RichHTML

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments