Abstract:

Objectives: To evaluate the effects of coenzyme-Q10, daidzein and lecithin alone or their combination on antioxidation system in mice. Methods: After 6 weeks of consecutive administration with the materials tested by gastric perfusion method, mice were sacrificed and their blood serum, liver and brain tissues were harvested to conduct biochemical tests related to antioxidation system. Besides, membrane lipid fluidity of brain neuron in hippocampus region was measured. Results: Individual administration of coenzyme-Q10 and lecithin resulted in a significant decrease of serum MDA content in mice. Compared with control mice, a significant decrease of MDA content in liver tissue was observed in mice administered daidzein alone (P＜0.05); in addition, GSH-Px activity in liver tissue, T-SOD activity in brain and liver tissues and MDA content in blood serum and brain and liver tissues revealed an obvious increase in mice with combined administration (P＜0.05); membrane fluidity of brain neuron in hippocampus region exhibited a significant amelioration in mice with individual administration of daidzein and lecithin or combined administration (P ＜ 0.05). Conclusion: Individual administration of coenzyme-Q10, daidzein and lecithin can improve antioxidation system, lipid metabolism and membrane fluidity of brain neuron in mice. A synergistic effect among them is also achieved.

Key words: coenzyme-Q10, daidzein, lecithin, antioxidation, synergistic effect