Effect of Abelmoschus manihot Flavonoids on Blood Lipid Levels of Hyperlipidemic Rats

Abstract

Abstract: Objective: To explore the effect of Abelmoschus manihot flavonoids on blood lipids of hyperlipidemic rats. Methods: Totally 100 SD rats were divided randomly into 6 groups: normal control group, high-fat control group, lovastatin positive control group at the dose of 10 mg/(kg·d), and flavonoid groups at low, middle and high doses (3, 30 mg/(kg·d) and 90 mg/(kg·d)). Except normal the control group, all groups were fed high-fat diet to establish a hyperlipidemia model. Normal control group and high-fat control group were given distilled water at the dose of 10 ml/(kg·d) once a day for 6 consecutive weeks. Serum TC, TG, HDL-C, LDL-C, and ox-LDL were determined after the last administration. Results: Compared with the control group, serum TC, TG, LDL-C and ox-LDL revealed a significantly reduction in all the model groups. However, no significant difference in HDL-C level was observed among these groups. Conclusion: The flavonoids can delay the formation and development of arteriosclerosis.

Key words: Abelmoschus manihot, flavonoids, hyperlipidemia

CLC Number:

TS201．6

References

[1] 彭志兵, 吴正平. 高效液相色谱-质谱法分析金花葵花中金丝桃苷[J]. 安徽农业科学, 2008, 36(23): 10028-10029.
[2] 刘临. 原子吸收光谱法测定金花葵中微量元素[J]. 微量元素与健康研究, 2008, 25(4): 17-29.
[3] PETTT L, LESNIK P, DACHET C, et a1. Tissue factor pathway inhibitor is expressed by human monocyte-derived macrophages: relationship to tissue factor induction by cholesterol and oxidized LDL[J]. Arterioscler Thromb Vaac Biol, 1999, 19(2): 309-315.
[4] MURRAY C J L, LOPEZ A D. Mortality by cause for eight regions of the world: global burden of disease study[J]. Lancet, 1997, 349: 1269-1276.
[5] 李楠, 刘元, 侯滨滨. 黄酮类化合物的功能特性[J]. 食品研究与开发, 2005, 26(6): 139-141.
[6] 吴名全, 雷波. 金花葵花中总黄酮的提取纯化及含量测定[J]. 农技服务, 2009, 26(10): 127-138.
[7] 夏文宽. 菜芙蓉花总黄酮的提取与抗氧化活性研究[D]. 江苏大学: 镇江, 2007.
[8] 林泽鹏, 张治伟, 金光临, 等．冠心病患者血脂和脂蛋白水平及与心功能的关系[J]. 中国康复理论与实践, 2005, 11(6): 427-428.
[9] 王敏, 魏益民, 高锦明. 苦荞麦总黄酮对高脂血大鼠血脂和抗氧化作用的影响[J]. 营养学报, 2006, 28(6): 502-509.
[10] LIBBY P. Inflammation and cardiovascular disease mechanisms[J]. Am J Clin Nutr, 2002, 83(2): 456S-460S.
[11] PARTHASARATHY S, RANKIN S M. The role of oxidized LDL in atherogenesis[J]．Prog Lipid Res, 1992, 31: 127-143.
[12] JUDITH A, BERLITER, ANDHEW D W. The role of oxidized lipoprotein in atherosclerosis[J]. Free Radic Biol and Med, 1996(5): 707-727.
[13] Canavesi M, Baldini N, Leonardi A, et a1. In vitro inhibitory efect of lereanidipine on cholesterol accumulation and matrix metalloproteinases secretion by maerophages [J]. J Cardiovase Pharmacol, 2004, 44(4): 416.
[14] 王继峰, 李峨, 李贡宇, 等. 大豆总黄酮对实验性大鼠高脂血症及脂肪肝的治疗作用[J]. 中国医药学报, 2001, 16(1): 23-27.
[15] Sanehez perez M J, Gonzalez R E, Santolaria F F, et a1. Lipid peroxidation and serum cytokines in acute alcoholic hepatiti[J]. Alcohol, 2006, 41(6): 593.