FOOD SCIENCE ›› 2012, Vol. 33 ›› Issue (15): 283-286.

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Effect of Total Flavonoids from Dendranthema morifolium (Ramat) Tzvel. cv. Chuju Flowers on Myocardial Ischemia Reperfusion Injury in Rats

  

  • Received:2011-08-22 Revised:2012-07-17 Online:2012-08-15 Published:2012-09-07
  • Contact: YU Hao E-mail:yhz_1230@163.com
  • Supported by:

    Effect and Mechanism of Chuju Total Flavonoids on Myocardial Ischemia-reperfusion Injury in Rats

Abstract: Objective: To observe the effect and underlying mechanism of total flavonoids extracted from Dendranthema morifolium (Ramat) Tzvel. cv. Chuju flowers on myocardial ischemia reperfusion injury (MIRI) in rats. Methods: Acute MIRI mouse models were created by reperfusion for 60 min after anterior interventricular branch of the left coronary artery for 30 min. The infarction area of myocardium, serum creatine kinase (CK) and lactate dehydrogenase (LDH) activities, SOD activity in serum and myocardium, and MDA content in serum and heart tissue were determined. Thrombus length, dry and wet weight of thrombi, and viscosity of whole blood and plasma were also evaluated. Results: Total flavonoids rom Dendranthema morifolium (Ramat) Tzvel. cv. Chuju flowers could decrease the infarction area of myocardium, reduce  serum CK and LDH activity, improve the activity of SOD in serum and heart tissue, decrease MDA content in serum and heart tissue, reduce thrombus length, wet weight and dry weight of thrombi in vitro, and improve the viscosity of whole blood. Conclusion: Total flavonoids from Dendranthema morifolium (Ramat) Tzvel. cv. Chuju flowers can protect against MIRI in rats.

Key words: total flavonoids from Dendranthema morifolium (Ramat) Tzvel. cv. Chuju flowers, Wistar rat, myocardial ischemia reperfusion injury, lipid preoxidation

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