Immunoregulatory Effect of Deer Antler Base Proteins on Mammary Gland Hyperplasia in Mice

Abstract

Abstract: Objective: To investigate the effect of deer antler base proteins on estrogen level and immune function in mice with mammary gland hyperplasia. Methods: Mouse models of mammary gland hyperplasia were established by combined injection of estradiol benzoate and progesterone. After administration with deer antler base proteins for 25 consecutive days, the mouse models were tested for serum estradiol level, uterus coefficient and immune organ coefficients. Results: In comparison with the model group, the treatment group showed a significant reduction in serum estradiol level and uterus coefficient of mice with mammary gland hyperplasia (P＜0.05) and a significant increase in thymus coefficient and spleen coefficient (P＜0.05). Conclusion: Deer antler base proteins regulate the secretion of estrogens and enhance immune function in mice.

Key words: deer antler base, protein, estradiol, immune function

CLC Number:

中图分类号：TS285.5 文献标识码：A 文章编号：

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Immunoregulatory Effect of Deer Antler Base Proteins on Mammary Gland Hyperplasia in Mice

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