Abstract: A high performance liquid chromatographic (HPLC) method was developed for determining bisphenol A (BPA) residue and migration in polycarbonate (PC) baby milk bottles. Solid-phase extraction (SPE) for analyte enrichment was used to study the effect of soaking time on BPA migration from PC baby bottles. BPA residues were detected in a certain brand of baby bottle at a level of 10.7 mg/kg. The migration of residual BPA from PC baby bottles to water reached the maximum level after exposure for 1–6 h, showed no obvious changes with increasing exposure time and basically reached equilibrium after 10 h exposure. During the whole process, the specific migration amount of BPA was 0.36 mg/kg, and the final concentration in water was 0.025 mg/L. The limit of detection of the HPLC method was 0.6 ng/mL (RSN = 3). The average recovery rates of BPA across three spike levels were 85.9%–89.5% with a relative standard deviation (RSD) of 0.78%–1.43% (n = 4).

Key words: baby bottles, high performance liquid chromatography (HPLC), bisphenol A (BPA), migration