Protective Effect of Black Rice Anthocyanin Compound Capsule on Experimental Hepatic Injury

Abstract

Abstract: Abstract: Establishments pathology model of carbon tetrachloride (CCl4)–induced hepatic injury in mice and cured by poured the black rice anthocyanin compound capsule in low concentration and high concentration into stomach, distilled water for the normal group, and plant oil for the suspending agents group. The content of SOD, MDA, GSH and the levels of TNF-α in liver homogenate were measured after 5wk. Hepatic pathological examination was observed．The result show that the black rice anthocyanin compound capsule can increase SOD activity obviously, clear MDA content directly in hepatic tissue, improve GSH content and reduce TNF-α level. The pathology analysis suggested that black rice anthocyanin compound capsule improve hepatic fibrosis in mice. Suspension agents basically have no influence on drug effect. Therefore the black rice anthocyanin compound capsule has a particular treatment effect on CCl4 hepatic injury

CLC Number:

TS218

References

[1]孔令瑶.黑米中生物活性物质的研究[D].无锡:江南大学,2008.
[2]曹小勇,李新生.黑米花色素苷类色素研究现状及展望[J].氨基酸和生物资源, 2002,24(1):3-6.
[3]王锋,邓洁,谭兴和,等.花色苷及其共色作用研究进展[J].食品科学,2008,29(2):472-476.
[4]Seok H N,Sun P C,Mi Y K,eta1.Antioxidative activities of bran extracts from twenty one pigmented rice cultivars[J].Food Chemistry,2006,94:613-620.
[5]王艳龙,石绍福,韩豪,等.中国黑米花色苷研究现状及展望[J]. 中国生化药物杂志,2010,31(1):63-66.
[6]李春阳,许时婴,王璋.葡萄籽原花青素结构单元的红外光谱分析[J].食品与生物技术学报,2005,24(4):47-51.
[7]Li xingsheng, Long shuming, Wu sanqiao, et al. Investigation of anthocyanin extraction from black rice and light stability of anthocyanin-containing alcoholic drink [J].CIGR Journal, 2011,13（Special issue）:151-159
[8]吴三桥,史隋孝,丁锐,等.黑米中花青苷色素的测定方法研究[J].氨基酸和生物资源,2002,24(3):66-68.
[9]Zhang Ming-wei，Guo Bao-jiang,Chi Jian-wei, et al．Antioxidations and their correlation with total flavones and anthocyanin contents in different black rice varieties[J]．Agric Sci China, 2005,38(7):1324-133.
[10]钱松.黑米花青苷对机体免疫生化功能影响的研究[D].温州:温州医学院,2009.
[11]侯方丽.黑米花色苷对CCL4诱导小鼠肝损伤的保护作用及其抗氧化机制[D]. 武汉:华中农业大学.2009
[12]郭红辉,凌文华.黑米花青苷研究进展[J].食品研究与开发，2008,29(3):133-135
[13]钟岩,李泽鸿,邵明富.黑米色素的提取方法及稳定性研究[J].北方园艺,2008,(10):71-73
[14]石绍福.黑米花青苷组分分析及软胶囊研制[D].汉中:陕西理工学院,2011.
[15]Lutz W .D.Weber,Meinrad Boll.Hepatotoxicity and Mechaiism of Action of Haloalkanes:Carbon Tetrachloride as a Toxicological Model [J].Critical Reviews in Toxicology,2001,33(2):105-132.
[16]柳茜,肖俊．当归多糖预防急性四氯化碳性肝损伤及其作用机制[J]中国医学研究与临床，2006,4（3）：4-5
[17]Kishore R,Hill J R,McMullen M R,et a1.ERK 1/2 and Egr-1contribute to increased TNF-alpha production in rat Kupffer cellsafter chronic ethanol feting[J].Am J Physiol Gastrointest LiverPhysiol,2002,282(1):6-15.