Abstract:

noxs Genes, which can mediate the generation of reactive oxygen species (ROS), are the “stress response
signaling molecules” which exist widely in animal and plant cells. Studies have shown that similar noxs genes are also
present in bacteria. When pathogenic bacteria face unfavorable living environmental conditions, these genes are activated
and then regulate the biofilm formation and bacterial virulence factors by mediating the generation of ROS. This paper
reviews the noxs genes in bacteria and their roles in mediating ROS generation in those processes.

Key words: noxs gene, biofilm formation, virulence regulation