Abstract:

Objective: To evaluate the effect of inulin on insulin resistance in trans fatty acids-fed mice. Methods: Inulin was
given at low, medium and high doses. Results: The intake of trans fatty acids elevated fasting blood glucose, fasting serum
insulin, insulin resistance index significantly (P < 0.01), and reduced insulin sensitivity index, islet β-cell function and T-SOD
significantly (P < 0.01). Inulin reduced fasting blood glucose and insulin resistance index, and increased insulin sensitivity
index and islet β-cell function, especially at the high dose, showing significant differences (P < 0.01) when compared with
the trans fatty acid group. Conclusion: Trans fatty acids can lead to insulin resistance in mice, and the intervention of inulin
can improve the symptoms, in particular at the high dose.

Key words: trans fatty acids, inulin, mice, insulin resistance, hyperlipidemia