Determination of Chlorpheniramine Residues in Foods of Animal and Plant Origin by GC-MS/MS

doi:10.7506/spkx1002-6630-20191104-036

FOOD SCIENCE ›› 2021, Vol. 42 ›› Issue (10): 311-315.doi: 10.7506/spkx1002-6630-20191104-036

• Safety Detection • Previous Articles Next Articles

Determination of Chlorpheniramine Residues in Foods of Animal and Plant Origin by GC-MS/MS

ZHOU Ruohao, LÜ Daizhu, MA Chen, LIANG Shuilian, XIANG Tantan, WANG Mingyue

(1. College of Food Science and Technology, Huazhong Agricultural University, Wuhan 430070, China; 2. Analysis and Testing Center, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China; 3. College of Tropical Crops, Hainan University, Haikou 570228, China)

Online:2021-05-25 Published:2021-06-02

Abstract

Abstract: In this study, an analytical method for the determination of chlorpheniramine residues in foods of animal and plant origin by gas chromatography-tandem mass spectrometry (GC-MS/MS) was developed. The samples were pretreated with a modified quick, easy, cheap, effective, rugged, safe (QuEChERS) method and solid phase extraction, and the analytes were separated on HP-5MS GC column and quantitatively determined by an external standard method. The experimental results showed that the method exhibited a good linear relationship in the range of 0.01–0.5 and 0.03–1 μg/mL with correlation coefficient R2 higher than 0.999 for banana and an animal food sample, respectively. The spiked recoveries for three matrixes were measured to be 80.6%–107.8%, with relative standard deviation (RSD) of 2.3%–8.5%. This method was characterized by simple operation and good reproducibility. It was suitable for batch sample detection, providing a technical basis for evaluating the risk of dietary exposure to chlorpheniramine.

Key words: gas chromatography-tandem mass spectrometry; foods of animal and plant origin; chlorpheniramine

CLC Number:

TS207.3

ZHOU Ruohao, LÜ Daizhu, MA Chen, LIANG Shuilian, XIANG Tantan, WANG Mingyue. Determination of Chlorpheniramine Residues in Foods of Animal and Plant Origin by GC-MS/MS[J]. FOOD SCIENCE, 2021, 42(10): 311-315.

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Determination of Chlorpheniramine Residues in Foods of Animal and Plant Origin by GC-MS/MS

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